Abstract :
Background and Aim: The second prevalent reason for urinary tract nosocomial infections and wounds is enterococci. Global outbreaks have been caused by multidrug resistance, particularly vancomycin-resistant enterococci, and their spread. The current investigation attempts to identify the distribution, susceptibility pattern, and prevalence of VRE (vancomycin-resistant enterococci) in diverse clinical isolates.
Materials and Methods: A cross-sectional, prospective study was carried out between December 2023 and May 2024 in the microbiology department of the tertiary care hospital. Approximately 76 distinct clinical isolates of enterococci were obtained from various clinical samples, including blood, pus, urine, and tissue fluids, sourced from both inpatient and outpatient departments, over the course of the study. The isolates were identified using both an antibiotic susceptibility test and a standard biochemical test in accordance with CLSI guidelines. The conventional techniques for identifying VRE were the Minimum Inhibitory Concentration test and the Kirby Bauer disc diffusion approach on Muller-Hinton agar.
Results: Of the 76 isolates, the majority (48.06%) came from urine, with blood cultures (33.08%) and pus swabs (5.66%) coming in second and third, respectively. According to susceptibility testing, 11.13% of people had VRE.
Conclusion: Patients with sepsis, wound infections, and urinary tract infections had increased rates of enterococcal infection. VRE was isolated from a variety of clinical isolates, and its prevalence (11.13%) suggests that MDR Enterococci have fewer options for antibiotic treatment. This emphasises the necessity of putting strong infection control measures in place, such as limiting the appropriate use of antibiotics, particularly vancomycin, in order to treat infections effectively and lower the mortality and normalcy rates related to hospital- acquired VRE infections.

Keyword : Prevalence,Enterococci, Vancomycin Resistant Enterococci Anti Microbial Susceptibility, Nosocomial Infections.